Freeman D J, Wenerstrom G, Spruance S L
Clin Pharmacol Ther. 1985 Jul;38(1):56-9. doi: 10.1038/clpt.1985.134.
Butylated hydroxytoluene (BHT) is a hydrophobic compound with in vitro activity against many enveloped viruses, including herpes simplex virus. The effect of topical therapy with 15% BHT in mineral oil on the course of recurrent herpes simplex labialis was examined in 30 patients in a double-blind, placebo-controlled pilot study in which treatment was initiated by the physician. Sixteen patients received BHT and 14 received the placebo mineral oil vehicle. The time from lesion onset to dry crust formation was slightly shorter among BHT recipients than among placebo recipients (2.0 and 2.4 days; P = 0.01). Duration of the vesicle-ulcer stages was likewise shorter (1.2 and 2.0 days; P = 0.09), and lesion virus excretion appeared to be less in the subjects who received BHT than in the controls, but these differences were not significant. There was no clinical or laboratory evidence of toxicity.
丁基化羟基甲苯（BHT）是一种疏水化合物，在体外对包括单纯疱疹病毒在内的许多包膜病毒具有活性。在一项由医生启动治疗的双盲、安慰剂对照的试点研究中，对30例复发性唇疱疹患者进行了15%BHT矿物油局部治疗对病程影响的研究。16例患者接受BHT治疗，14例患者接受安慰剂矿物油载体治疗。BHT治疗组从病损开始到结痂干燥的时间比安慰剂治疗组略短（分别为2.0天和2.4天；P=0.01）。水疱-溃疡期的持续时间同样较短（分别为1.2天和2.0天；P=0.09），接受BHT治疗的受试者病损病毒排泄似乎比对照组少，但这些差异不显著。没有临床或实验室毒性证据。
