早期由患者自行使用外用10%阿昔洛韦治疗唇疱疹。
Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir.
作者信息
Spruance S L, Crumpacker C S, Schnipper L E, Kern E R, Marlowe S, Arndt K A, Overall J C
出版信息
Antimicrob Agents Chemother. 1984 May;25(5):553-5. doi: 10.1128/AAC.25.5.553.
Abstract
To determine whether topical acyclovir in polyethylene glycol could reduce the severity of herpes simplex labialis if applied immediately after onset of a recurrence, 10% acyclovir in polyethylene glycol ointment or polyethylene glycol alone was prospectively dispensed to 352 patients in a double-blind, randomized trial. Sixty-nine subjects initiated treatment in the prodrome (57%) or erythema (43%) stage and were followed by clinical and virological criteria. The healing time (6.0 days), maximum lesion area (42 mm2), vesicle or ulcer formation (91%), and maximum lesion virus titer (4.8 log10 PFU) in the drug recipients were not reduced in comparison with those who received the vehicle (5.2 days, 30 mm2, 75%, and 4.5 log10 PFU, respectively). Topical acyclovir in polyethylene glycol was ineffective for the treatment of herpes labialis despite an optimum therapeutic opportunity.
摘要
为了确定复发刚开始时立即应用聚乙二醇中的局部阿昔洛韦是否能减轻唇疱疹的严重程度，在一项双盲随机试验中，前瞻性地向352例患者分发了聚乙二醇软膏中含10%阿昔洛韦的制剂或仅含聚乙二醇的制剂。69名受试者在前驱期（57%）或红斑期（43%）开始治疗，并按照临床和病毒学标准进行随访。与接受赋形剂的患者相比（分别为5.2天、30平方毫米、75%和4.5 log10 PFU），接受药物治疗的患者的愈合时间（6.0天）、最大皮损面积（42平方毫米）、水疱或溃疡形成（91%）以及最大皮损病毒滴度（4.8 log10 PFU）并未降低。尽管有最佳治疗时机，但聚乙二醇中的局部阿昔洛韦对唇疱疹治疗无效。
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