INSERM U955, équipe 3, Créteil, France.
Université Paris-Est, UMR_S955, DHU A-TVB, UPEC, Créteil, France.
Aging Cell. 2018 Aug;17(4):e12793. doi: 10.1111/acel.12793. Epub 2018 Jun 11.
The cellular mechanisms responsible for aging are poorly understood. Aging is considered as a degenerative process induced by the accumulation of cellular lesions leading progressively to organ dysfunction and death. The free radical theory of aging has long been considered the most relevant to explain the mechanisms of aging. As the mitochondrion is an important source of reactive oxygen species (ROS), this organelle is regarded as a key intracellular player in this process and a large amount of data supports the role of mitochondrial ROS production during aging. Thus, mitochondrial ROS, oxidative damage, aging, and aging-dependent diseases are strongly connected. However, other features of mitochondrial physiology and dysfunction have been recently implicated in the development of the aging process. Here, we examine the potential role of the mitochondrial permeability transition pore (mPTP) in normal aging and in aging-associated diseases.
细胞衰老的机制尚不清楚。衰老被认为是一种退行性过程，由细胞损伤的积累引起，导致器官功能逐渐丧失和死亡。自由基衰老理论长期以来被认为是解释衰老机制最相关的理论。由于线粒体是活性氧（ROS）的重要来源，因此该细胞器被认为是该过程中的关键细胞内参与者，并且大量数据支持线粒体 ROS 产生在衰老过程中的作用。因此，线粒体 ROS、氧化损伤、衰老和与衰老相关的疾病密切相关。然而，线粒体生理学和功能障碍的其他特征最近也被牵连到衰老过程的发展中。在这里，我们研究了线粒体通透性转换孔（mPTP）在正常衰老和与衰老相关疾病中的潜在作用。
