在混合研磨机中无溶剂条件下，机械化学铑（III）和金（I）催化吲哚的C-H键炔基化反应
Mechanochemical Rhodium(III)- and Gold(I)-Catalyzed C-H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills.
作者信息
Hermann Gary N, Unruh Marvin T, Jung Se-Hyeong, Krings Maik, Bolm Carsten
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
出版信息
Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10723-10727. doi: 10.1002/anie.201805778. Epub 2018 Jun 28.
Mechanochemical activations in Rh - and Au -catalyzed C-H alkynylations lead selectively to C - and C -alkynylated indoles. The processes show excellent functional group tolerance, do not require additional heating and proceed under solventless conditions. Compared to solvent-based standard protocols, the reaction times are shorter and the catalyst quantities lower resulting in high product yields under ambient atmosphere in mixer mills.
铑催化和金催化的C-H炔基化反应中的机械化学活化选择性地生成C-和C-炔基化吲哚。这些过程显示出优异的官能团耐受性，无需额外加热，且在无溶剂条件下进行。与基于溶剂的标准方法相比，反应时间更短，催化剂用量更低，从而在搅拌磨的环境气氛下实现高产物收率。
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