Méndez-Gálvez Carolina, Barnå Fredrik, Olsthoorn Boris, Estébanez Rosich David, Gates Paul J, Pilarski Lukasz T
Department of Chemistry - BMC, Uppsala University, P.O. Box 576, Uppsala 75123, Sweden.
School of Chemistry, University of Bristol, Cantock's Close, Clifton, Bristol BS8 1TS, United Kingdom.
J Org Chem. 2025 Jul 4;90(26):8846-8856. doi: 10.1021/acs.joc.5c00109. Epub 2025 Jun 18.
A low-cost, operationally simple approach to eight different solventless Rh-, Ru-, Ir-, and Pd-catalyzed C-H and C-X functionalizations, as well as the synthesis of difficult-to-make rhodacyclic complexes, is presented. The method uses open-air grinding and heating, is reproducible, gives competitive yields compared with automated ball milling protocols, and can be extended to the late-stage modification of various bioactive compounds.
本文介绍了一种低成本、操作简单的方法，可用于八种不同的无溶剂铑、钌、铱和钯催化的C-H和C-X官能团化反应，以及难以制备的铑环配合物的合成。该方法采用露天研磨和加热，具有可重复性，与自动球磨方案相比产率具有竞争力，并且可以扩展到各种生物活性化合物的后期修饰。
