a Inner Mongolia People's Hospital, Inner Mongolia , China.
b Wuhan General Hospital of Guangzhou Commend , Wuhan , China.
Clin Exp Hypertens. 2018;40(6):514-517. doi: 10.1080/10641963.2017.1403618. Epub 2018 Jun 11.
To investigate the influence of IL-6 single nucleotide polymorphisms (SNPs), additional gene-gene and gene-environment interactions on coronary artery disease (CAD) risk.
A total of 751 participants (429 CAD patients and 322 controls) were recruited in this study. Logistic regression analysis was conducted to evaluate the association of IL-6 SNPs with CAD risk and generalized multifactor dimensionality reduction (GMDR) was performed to investigate the best interaction combinations for gene-gene and gene-environment interactions.
CAD risk is significantly higher in carriers of C allele of the rs1800795 polymorphism than those with GG genotype (CC + CG versus GG, adjusted OR (95%CI) = 2.07 (1.56-2.86), p < 0.001). GMDR analysis revealed rs1800795 was significantly interacted with tobacco smoking and alcohol drinking in two-locus model (p < 0.0010). Current smokers with CC or CG of rs1800795 genotype have the highest CAD risk, OR (95%CI) = 3.22 (2.45-3.94) and current drinkers with CC or CG of rs1800795 genotype have the highest CAD risk, OR (95%CI) = 3.17 (2.20-4.24).
The C allele of rs1800795 within IL-6 gene promoter, rs1800795-tobacco smoking and rs1800795-alcohol drinking interaction were all associated with increased CAD risk.
研究白细胞介素 6（IL-6）单核苷酸多态性（SNP）、附加基因-基因和基因-环境相互作用对冠心病（CAD）风险的影响。
本研究共纳入 751 名参与者（429 名 CAD 患者和 322 名对照）。采用 logistic 回归分析评估 IL-6 SNP 与 CAD 风险的关系，并采用广义多因素维度缩减（GMDR）分析基因-基因和基因-环境相互作用的最佳交互组合。
与 GG 基因型相比，rs1800795 等位基因 C 的携带者 CAD 风险显著升高（CC+CG 与 GG，调整 OR（95%CI）=2.07（1.56-2.86），p<0.001）。GMDR 分析显示 rs1800795 与吸烟和饮酒在双位点模型中存在显著交互作用（p<0.0010）。携带 rs1800795 CC 或 CG 基因型的当前吸烟者 CAD 风险最高，OR（95%CI）=3.22（2.45-3.94），携带 rs1800795 CC 或 CG 基因型的当前饮酒者 CAD 风险最高，OR（95%CI）=3.17（2.20-4.24）。
IL-6 基因启动子内 rs1800795 的 C 等位基因、rs1800795-吸烟和 rs1800795-饮酒相互作用均与 CAD 风险增加相关。
