Rosso Marcelie Priscila de Oliveira, Buchaim Daniela Vieira, Kawano Natália, Furlanette Gabriela, Pomini Karina Torres, Buchaim Rogério Leone
Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Alameda Dr. Octávio Pinheiro Brisola 9-75, Vila Nova Cidade Universitária, Bauru, São Paulo CEP 17012-901, Brazil.
Medical School, Discipline of Human Morphophysiology, University of Marilia (UNIMAR), Av. Higino Muzi Filho, 1001 Campus Universitário, Jardim Araxa, Marília, São Paulo CEP 17525-902, Brazil.
Bioengineering (Basel). 2018 Jun 9;5(2):44. doi: 10.3390/bioengineering5020044.
Photobiomodulation therapy (PBMT) has been investigated because of its intimate relationship with tissue recovery processes, such as on peripheral nerve damage. Based on the wide range of benefits that the PBMT has shown and its clinical relevance, the aim of this research was to carry out a systematic review of the last 10 years, ascertaining the influence of the PBMT in the regeneration of injured peripheral nerves. The search was performed in the PubMed/MEDLINE database with the combination of the keywords: low-level laser therapy AND nerve regeneration. Initially, 54 articles were obtained, 26 articles of which were chosen for the study according to the inclusion criteria. In the qualitative aspect, it was observed that PBMT was able to accelerate the process of nerve regeneration, presenting an increase in the number of myelinated fibers and a better lamellar organization of myelin sheath, besides improvement of electrophysiological function, immunoreactivity, high functionality rate, decrease of inflammation, pain, and the facilitation of neural regeneration, release of growth factors, increase of vascular network and collagen. It was concluded that PBMT has beneficial effects on the recovery of nerve lesions, especially when related to a faster regeneration and functional improvement, despite the variety of parameters.
由于光生物调节疗法（PBMT）与组织恢复过程密切相关，如对外周神经损伤的影响，因此对其进行了研究。基于PBMT所显示的广泛益处及其临床相关性，本研究的目的是对过去10年进行系统综述，确定PBMT对受损外周神经再生的影响。在PubMed/MEDLINE数据库中使用关键词“低强度激光疗法”和“神经再生”进行搜索。最初获得了54篇文章，根据纳入标准选择了其中26篇文章进行研究。在定性方面，观察到PBMT能够加速神经再生过程，除了改善电生理功能、免疫反应性、高功能率、减轻炎症、疼痛以及促进神经再生、生长因子释放、增加血管网络和胶原蛋白外，还表现为有髓纤维数量增加和髓鞘板层组织更好。得出的结论是，尽管存在各种参数，但PBMT对神经损伤的恢复具有有益作用，尤其是在更快的再生和功能改善方面。
