Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, SP, Brazil.
Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, SP, Brazil; Medical School, Discipline of Human Morphophysiology, University of Marilia (UNIMAR), Marília, SP, Brazil; Medical School, Discipline of Neuroanatomy, University Center of Adamantina (UNIFAI), Adamantina, SP, Brazil.
Injury. 2019 Nov;50(11):1853-1867. doi: 10.1016/j.injury.2019.09.031. Epub 2019 Sep 21.
Photobiomodulation therapy (PBMT) using low-level laser influences the release of several growth factors involved in the formation of epithelial cells, fibroblasts, collagen and vascular proliferation, besides accelerating the synthesis of bone matrix due to the increased vascularization and lower inflammatory response, with significant increase of osteocytes in the irradiated bone. Considering its properties, beneficial effects and clinical relevance, the aim of this review was to analyze the scientific literature regarding the use of PBMT in the process of bone defect repair.
Electronic search was carried out in PubMed/MEDLINE and Web of Science databases with combination of the descriptors low-level laser therapy AND bone repair, considering the period of publication until the year 2018.
The literature search identified 254 references in PubMed/MEDLINE and 204 in Web of Science, of which 33 and 4 were selected, respectively, in accordance with the eligibility requirements. The analysis of researches showed articles using PBMT in several places of experimentation in the subjects, different types of associated biomaterials, stimulatory effects on cell proliferation, besides variations in the parameters of use of laser therapy, mainly in relation to the wavelength and density of energy. Only four articles reported that the laser did not improve the osteogenic properties of a biomaterial.
Many studies have shown that PBMT has positive photobiostimulatory effects on bone regeneration, accelerating its process regardless of parameters and the use of biomaterials. However, standardization of its use is still imperfect and should be better studied to allow correct application concerning the utilization protocols.
低水平激光的光生物调节疗法（PBMT）会影响参与上皮细胞、成纤维细胞、胶原蛋白和血管增殖形成的几种生长因子的释放，此外，由于血管生成增加和炎症反应降低，骨基质的合成也会加速，从而导致辐照骨中的骨细胞数量显著增加。鉴于其特性、有益效果和临床相关性，本综述旨在分析关于 PBMT 在骨缺损修复过程中的应用的科学文献。
在 PubMed/MEDLINE 和 Web of Science 数据库中进行电子检索，使用的检索词为低水平激光疗法 AND 骨修复，并考虑到出版物的时间段为 2018 年之前。
在 PubMed/MEDLINE 中检索到 254 篇参考文献，在 Web of Science 中检索到 204 篇，根据纳入标准分别选择了 33 篇和 4 篇。对研究的分析表明，研究使用了 PBMT 在实验对象的不同部位，结合了不同类型的相关生物材料，对细胞增殖有刺激作用，激光治疗的使用参数也存在差异，主要是波长和能量密度方面。只有四篇文章报道激光没有改善生物材料的成骨性能。
许多研究表明，PBMT 对骨再生具有积极的光生物刺激作用，可加速其过程，无论参数和生物材料如何。然而，其使用的标准化仍不完善，应进行更好的研究，以便在利用方案中正确应用。
