Jin Zhi-Chao, Cai Qun-Bin, Zeng Zhi-Kui, Li Ding, Li Yue, Huang Pei-Zhen, Zheng Xiao-Hui
Department of Traumatic Orthopedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
Zhongguo Gu Shang. 2018 May 25;31(5):488-492. doi: 10.3969/j.issn.1003-0034.2018.05.018.
Treatment of large bone defects caused by trauma, osteomyelitis, and tumors has been a major challenge in clinical. In the past, there have been many ways to repair and reconstruct the large bone defects. However, there is a long period of treatment, high technical requirement and complications such as ununion. After Masquelet reported the induced membrane technology in 2000, the technique was widely used in treatment of trauma, osteomyelitis, and large bone defects caused by tumors. It has been obtained good results. It has the advantages of short course, high healing rate, easy operation and easy to master. The induced membrane has unique structural characteristics and biological characteristics. There are many kinds of osteogenic factors that are included in the membrane, such as vascular endothelial growth factor, and morphogenetic protein-2, transforming growth factor-β1, etc. These osteogenic factors contribute to accelerate bone healing. With the development of induced membrane technology. The technology of Reamer Irrigator Aspirator technology, engineering tissue technology and internal fixation is used in clinic.It can provide bone source, promote bone defect reconstruction, improve long-term limb function and reduce complications.This paper retrospectively summarizes the experimental research and clinical progress of Masquelet technique in the treatment of large bone defects.
创伤、骨髓炎和肿瘤所致大骨缺损的治疗一直是临床上的一大挑战。过去，修复和重建大骨缺损有多种方法。然而，治疗周期长、技术要求高且存在骨不连等并发症。2000年Masquelet报道诱导膜技术后，该技术被广泛应用于创伤、骨髓炎及肿瘤所致大骨缺损的治疗，并取得了良好效果。它具有疗程短、愈合率高、操作简便且易于掌握的优点。诱导膜具有独特的结构特点和生物学特性。膜内包含多种成骨因子，如血管内皮生长因子、形态发生蛋白-2、转化生长因子-β1等。这些成骨因子有助于加速骨愈合。随着诱导膜技术的发展，扩髓-冲洗-吸引技术、工程组织技术及内固定技术在临床上得到应用，可提供骨源、促进骨缺损重建、改善肢体长期功能并减少并发症。本文回顾性总结了Masquelet技术治疗大骨缺损的实验研究及临床进展。
