College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Carbohydr Polym. 2018 Sep 15;196:225-232. doi: 10.1016/j.carbpol.2018.05.020. Epub 2018 May 7.
Inspired by the supramolecular structure of cellulose, cellulose-gelatin supramolecular hydrogels with high strength and pH-sensitivity were constructed in a basic-based solvent system, ethylene diamine/potassium thiocyanate (EDA/KSCN) with the aid of cyclic freezing-thawing. The investigation on the characteristics of supramolecular hydrogels revealed that repeated freezing-thawing cycles played an important role in the formation of the physical cross-linked supramolecular network structure between cellulose and gelatin. The mechanical properties of supramolecular hydrogels were much higher than pure cellulose and gelatin hydrogel, and the compressive strength was 9.6 times higher than that of pure gelatin hydrogel. The synergistic effect between hydrogen-bonding interaction and the reinforcement of regenerated cellulose nanofibrils (CNF) contributed to the superior mechanical performance. Furthermore, the swelling kinetics tests showed that the supramolecular hydrogels exhibited excellent pH-responsibility, indicating potential applications in biomedical fields. Thus, a straightforward route to construct natural polymer-based hydrogels with supramolecular structure through physical crosslinking strategy without employing hazardous crosslinking agents was developed, paving the way for the design of new types of hydrogels.
受纤维素超分子结构的启发，在碱性溶剂体系（乙二胺/硫氰酸钾（EDA/KSCN））中，通过循环冷冻-解冻的方法构建了具有高强度和 pH 敏感性的纤维素-明胶超分子水凝胶。对超分子水凝胶特性的研究表明，反复的冻融循环在纤维素和明胶之间形成物理交联的超分子网络结构中起着重要作用。超分子水凝胶的力学性能远高于纯纤维素和明胶水凝胶，压缩强度比纯明胶水凝胶高 9.6 倍。氢键相互作用和再生纤维素纳米纤维（CNF）的增强协同效应有助于提高力学性能。此外，溶胀动力学测试表明，超分子水凝胶表现出优异的 pH 响应性，表明其在生物医学领域有潜在的应用。因此，开发了一种通过物理交联策略构建具有超分子结构的天然聚合物水凝胶的简单方法，无需使用危险的交联剂，为设计新型水凝胶铺平了道路。
