Rao Zhilu, Dong Yitong, Liu Jie, Zheng Xuejing, Pei Ying, Tang Keyong
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450001, China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450001, China.
Int J Biol Macromol. 2022 Dec 1;222(Pt B):3155-3167. doi: 10.1016/j.ijbiomac.2022.10.088. Epub 2022 Oct 13.
Herein, a strong and stable gelatin-based composite hydrogel was fabricated by incorporation of amino-functionalized microfibrillated cellulose (AMFC) into gelatin matrix along with genipin crosslinking. The hydrogel consists of chemical and physical crosslinks among gelatin chains and AMFC fibrils. The morphology, swelling behavior and compressive properties of the composite hydrogels were investigated. The results show that the mechanical properties and structural stability of the gelatin hydrogels were improved remarkably by the addition of AMFC due to the formation of a hybrid network structure. The composite hydrogel has a compressive strength up to 1.52 MPa at a strain of 80 %, which is 41.2 and 1.8 times higher than that of the conventional physical and genipin-crosslinked gelatin hydrogels, respectively. Moreover, the developed gelatin-based composite hydrogels reinforced with AMFC exhibit good enzymatic stability, high surface hydrophobicity, tunable swelling property and excellent biocompatibility, which are expected to have potential applications in biomedical and pharmaceutical fields.
在此，通过将氨基官能化微纤化纤维素（AMFC）与京尼平交联一起掺入明胶基质中，制备了一种坚固且稳定的明胶基复合水凝胶。该水凝胶由明胶链和AMFC原纤维之间的化学和物理交联组成。研究了复合水凝胶的形态、溶胀行为和压缩性能。结果表明，由于形成了杂化网络结构，添加AMFC显著提高了明胶水凝胶的力学性能和结构稳定性。该复合水凝胶在80%应变下的抗压强度高达1.52MPa，分别比传统物理交联和京尼平交联的明胶水凝胶高41.2倍和1.8倍。此外，用AMFC增强的明胶基复合水凝胶表现出良好的酶稳定性、高表面疏水性、可调溶胀性能和优异的生物相容性，有望在生物医学和制药领域具有潜在应用。
