Tremblay G, Buell R H, Seemayer T A
Am J Surg Pathol. 1977 Jun;1(2):155-66. doi: 10.1097/00000478-197706000-00006.
Elastosis, an abundance of elastic tissue, is commonly present in breast carcinoma. However, its diagnostic significance remaines an unsettled issue. This study documents 17 cases of elastosis occurring in a distinctive benign sclerosing ductal lesion of the female breast (Fenoglio and Lattes: Cancer 33: 691-700, 1974). Elastosis was characterized by staining reactions and, in several instances, by elastase digestion and electron microscopy. Yellow streaks and flecks may be apparent grossly and probably reflect the increased elastic tissue. Histologically, the lesion is generally stellate with central sclerosis and marked peripheral intraductal and ductular hyperplasia which is often papillary. Elastosis, which may be marked, is a constant finding and is predominantly periductal in location. It is emphasized that the gross and histologic features of the lesion may mimic carcinoma and that elastosis may be found in benign ductal lesions of the breast.
弹性组织增生，即大量弹性组织的存在，在乳腺癌中很常见。然而，其诊断意义仍是一个未解决的问题。本研究记录了17例发生在女性乳腺一种独特的良性硬化性导管病变中的弹性组织增生病例（费诺利奥和拉特斯：《癌症》33: 691 - 700，1974年）。弹性组织增生通过染色反应进行表征，在一些情况下还通过弹性蛋白酶消化和电子显微镜进行表征。黄色条纹和斑点在大体上可能很明显，可能反映了弹性组织的增加。组织学上，病变通常呈星状，有中央硬化以及明显的外周导管内和小导管增生，增生常呈乳头状。弹性组织增生可能很明显，是一个恒定的发现，主要位于导管周围。需要强调的是，该病变的大体和组织学特征可能类似癌，并且弹性组织增生可能在乳腺良性导管病变中出现。
