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主要组织相容性复合体I类基因的DNA多态性及其与血清学定义单倍型的关联。

DNA polymorphism of the major histocompatibility class I genes and their association with serologically defined haplotypes.

作者信息

Driesel A J, Römer K, Schunter F, Laryea M D, Schneider E M, Wernet P, Henke J, Basler M, Kömpf J

出版信息

Immunogenetics. 1985;21(6):529-38. doi: 10.1007/BF00395877.

DOI:10.1007/BF00395877
PMID:2989164
Abstract

DNA of unrelated persons as well as members of families that were totally or partially homozygous or completely heterozygous on the loci of the major histocompatibility class I genes has been isolated from peripheral blood lymphocytes and blot hybridized with the class I pseudogene pHLA 12.4 probe. The autoradiographic DNA patterns were discussed and compared with well-defined serological features. Positive associations with serologically typed alleles had been demonstrated for HLA-A1,11; -A2; -A3; -B7; -B14; -B35; -Bw41; and -Cw5.

摘要

已从外周血淋巴细胞中分离出无关个体以及在主要组织相容性复合体I类基因位点上完全或部分纯合或完全杂合的家庭成员的DNA，并与I类假基因pHLA 12.4探针进行印迹杂交。讨论了放射自显影DNA图谱，并与明确的血清学特征进行了比较。已证明HLA-A1、11；-A2；-A3；-B7；-B14；-B35；-Bw41；和-Cw5与血清学分型的等位基因呈正相关。

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本文引用的文献

1
Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.功能性I类HLA基因HLA - A3的完整核苷酸序列：对HLA基因进化的启示
EMBO J. 1984 Apr;3(4):887-94. doi: 10.1002/j.1460-2075.1984.tb01901.x.
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Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3).编码功能性人类I类组织相容性抗原（HLA - CW3）的基因的完整核苷酸序列。
EMBO J. 1984 Apr;3(4):879-85. doi: 10.1002/j.1460-2075.1984.tb01900.x.
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Isolation of HLA locus-specific DNA probes from the 3'-untranslated region.
Immunology. 1987 Mar;60(3):475-7.
从3'非翻译区分离HLA基因座特异性DNA探针。
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5175-8. doi: 10.1073/pnas.81.16.5175.
4
A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.连接补体基因C4、C2和B因子的人类主要组织相容性复合体III类区域的分子图谱。
Nature. 1984;307(5948):237-41. doi: 10.1038/307237a0.
5
Exon/intron organization and complete nucleotide sequence of an HLA gene.一个HLA基因的外显子/内含子结构及完整核苷酸序列
Proc Natl Acad Sci U S A. 1982 Feb;79(3):893-7. doi: 10.1073/pnas.79.3.893.
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Segregation and mapping analysis of polymorphic HLA class I restriction fragments: detection of a novel fragment.多态性HLA I类限制性片段的分离与图谱分析：一种新片段的检测
Science. 1983 Oct 7;222(4619):72-4. doi: 10.1126/science.6312559.
7
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Proc Natl Acad Sci U S A. 1983 Oct;80(20):6289-92. doi: 10.1073/pnas.80.20.6289.
8
Polymorphic restriction endonuclease fragment segregates and correlates with the gene for HLA-B8.多态性限制性内切酶片段分离并与HLA - B8基因相关。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1665-8. doi: 10.1073/pnas.80.6.1665.
9
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Cell. 1982 Mar;28(3):489-98. doi: 10.1016/0092-8674(82)90203-3.
10
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Science. 1981 Jun 12;212(4500):1229-38. doi: 10.1126/science.6165083.