Kita E, Matsuura H, Kashiba S
J Infect Dis. 1981 Jan;143(1):67-70. doi: 10.1093/infdis/143.1.67.
Intravaginal inoculation of approximately 10(6) piliated gonococci into female mice at different stages of the estrous cycle without any antibiotic pretreatment resulted in gonococcal endometritis. The percentage of mice with positive cultures for Neisseria gonorrhoeae one week after challenge was at least 80%, regardless of at which estrous stage the mice were inoculated. Recovery of gonococci from the uterus continued for more than one month, and the recovery rate appeared to depend on the estrous stage at inoculation. Serum levels of antibodies to crude outer membrane complex began rising one week after inoculation with gonococci and reached a maximum three week after challenge. This animal model is proposed for the study of gonococcal genital infection.
在不进行任何抗生素预处理的情况下，于发情周期的不同阶段向雌性小鼠阴道内接种约10⁶个菌毛淋病奈瑟菌，可导致淋菌性子宫内膜炎。攻毒后一周，淋病奈瑟菌培养阳性的小鼠百分比至少为80%，无论小鼠在哪个发情阶段接种。从子宫中回收淋病奈瑟菌持续超过一个月，回收率似乎取决于接种时的发情阶段。接种淋病奈瑟菌一周后，针对粗制外膜复合物的血清抗体水平开始上升，并在攻毒后三周达到最大值。该动物模型被提议用于研究淋菌性生殖器感染。
