Department of the Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical university, Chongqing Medical University, Chongqing, 400016, China.
Department of the Gastrointestinal Surgery, The First Affiliated hospital of Chongqing Medical university, Chongqing Medical University, Chongqing, 400016, China.
Sci Rep. 2018 Jun 11;8(1):8900. doi: 10.1038/s41598-018-26199-6.
We aimed to compare the overall survival (OS) and standardized mortality rate (SMR) of the male breast cancer (MBC) with female breast cancer (FBC) after propensity score matching. Based on the Surveillance, Epidemiology, and End Results (SEER), the early breast cancer patients (TNM) were extracted from 1998-2007. This study included 1,111 and 2,151 patients with early MBC and FBC, respectively, whose clinicopathological characteristics were well balanced. At a mean follow-up time of 97 months, 10-year OS rate was 58.3% in the MBC group and 68.7% in the FBC (log-rank test, P < 0.001; hazard ratio (HR) = 1.45, 95% confidence interval (CI) = 1.29 to 1.64). Adjusted HR for OS between MBC and FBC were revealed from propensity score matched-multivariable Cox proportional hazards models (HR = 1.53, 95% CI = 1.35 to 1.73). Similar adjusted SMRs between MBC and FBC ((SMR = 1.98, 95% CI = 1.83,2.14) for FBC and (SMR = 2.07, 95% CI = 1.88-2.28) for MBC) were observed. The nomogram was constructed for FBC, and predicted probabilities were generally good (C-index = 0.71), whose area under curve is higher than TNM stage classification (0.74 vs 0.62). OS was significantly decreased among early MBC patients compared with FBC, but similar SMRs and its trends by age groups were observed between MBC and FBC except for young patients.
我们旨在通过倾向评分匹配比较男性乳腺癌（MBC）与女性乳腺癌（FBC）的总生存（OS）和标准化死亡率（SMR）。基于监测、流行病学和最终结果（SEER），从 1998 年至 2007 年提取了早期乳腺癌（TNM）患者。本研究分别纳入了 1111 例和 2151 例早期 MBC 和 FBC 患者，两组患者的临床病理特征均得到了很好的平衡。在平均 97 个月的随访时间后，MBC 组的 10 年 OS 率为 58.3%，FBC 组为 68.7%（对数秩检验，P<0.001；风险比（HR）=1.45，95%置信区间（CI）=1.29 至 1.64）。从倾向评分匹配多变量 Cox 比例风险模型中发现，MBC 和 FBC 之间调整后的 OS 比值 HR 为 1.53（95%CI=1.35 至 1.73）。在 MBC 和 FBC 之间观察到相似的调整后 SMR（MBC 为 SMR=2.07，95%CI=1.88 至 2.28），FBC 为 SMR=1.98，95%CI=1.83 至 2.14）。为 FBC 构建了列线图，预测概率普遍较好（C 指数=0.71），其曲线下面积高于 TNM 分期分类（0.74 比 0.62）。与 FBC 相比，早期 MBC 患者的 OS 显著降低，但除了年轻患者外，MBC 和 FBC 之间观察到 SMR 及其按年龄组的趋势相似。
