Nishikaze O, Furuya E, Kawamura M
Int J Tissue React. 1985;7(1):1-9.
The management of inflammation, based on an overall, coordinated observation of the inflammatory system, requires the assessment of the validity and biological significance of the various components in inflammation, a procedure that is more reliable than the interpretation of individual measurements in isolation. Such an overall approach, here developed from the model of carrageenin-induced inflammation, also predicates that lysosomal enzymes, lipid peroxide and proamidase (related, respectively, to the inflammatory response in a narrow sense, to tissue damage and to tissue repair) are three basic parameters required when studying inflammatory processes. This overall approach, moreover, shows that the inflammatory process must be regarded as being diachronic, and that in the light of the observation of exudate fluid it can be divided into three main stages, namely an early stage of exudation related to lipid peroxide, an intermediate stage of exudate dilution related to granuloma amidase, and a later stage of exudate concentration related to granuloma amidase and plasma protein.
基于对炎症系统进行全面、协调观察的炎症管理，需要评估炎症中各个成分的有效性和生物学意义，这一过程比孤立地解释个别测量结果更为可靠。这里从角叉菜胶诱导的炎症模型发展而来的这种整体方法，还断定溶酶体酶、脂质过氧化物和前酰胺酶（分别与狭义的炎症反应、组织损伤和组织修复相关）是研究炎症过程时所需的三个基本参数。此外，这种整体方法表明，炎症过程必须被视为是历时性的，并且根据对渗出液的观察，它可以分为三个主要阶段，即与脂质过氧化物相关的渗出早期、与肉芽肿酰胺酶相关的渗出液稀释中期以及与肉芽肿酰胺酶和血浆蛋白相关的渗出液浓缩后期。
