Nishikaze O, Furuya E, Takita H
Int J Tissue React. 1985;7(1):11-9.
Coordinated observation of various factors in the inflammatory system and their relations shows that the levels of proamidase in granuloma pouch fluid in carrageenin-induced inflammation increase during the healing process whereas the proamidase shows (1) remarkably low values in rats injected with high doses of carrageenin, (2) low values in the earlier stages of inflammation with tissue damage (high values of fluid lipid peroxide and lactate dehydrogenase) and with phagocytosis (high values of fluid peroxidase and beta-glucuronidase), and (3) high values in the later stages where wound healing is progressing (high values of protein in plasma, fluid and granuloma pouch tissue and low values of fluid volume, fluid peroxidase, beta-glucuronidase and pouch tissue weight). In short, proamidase shows low values in the stage of tissue damage and constantly increasing values during the process of healing. Thus the measurement of proamidase, which reflects the degree of wound healing, provides an important parameter for a broad, coordinated observation of the inflammatory process, and may enable the management of inflammation.
对炎症系统中各种因素及其相互关系的协同观察表明，在角叉菜胶诱导的炎症中，肉芽肿袋液中的前酰胺酶水平在愈合过程中升高，而前酰胺酶表现为：（1）在注射高剂量角叉菜胶的大鼠中值极低；（2）在伴有组织损伤（液体脂质过氧化物和乳酸脱氢酶值高）以及吞噬作用（液体过氧化物酶和β-葡萄糖醛酸酶值高）的炎症早期值低；（3）在伤口愈合进展的后期值高（血浆、液体和肉芽肿袋组织中的蛋白值高，而液体体积、液体过氧化物酶、β-葡萄糖醛酸酶和袋组织重量值低）。简而言之，前酰胺酶在组织损伤阶段值低，在愈合过程中持续升高。因此，反映伤口愈合程度的前酰胺酶测量为广泛、协同观察炎症过程提供了一个重要参数，并且可能有助于炎症的控制。
