Yoshikawa Toru, Zempo-Miyaki Asako, Kumagai Hiroshi, Myoenzono Kanae, So Rina, Tsujimoto Takehiko, Tanaka Kiyoji, Maeda Seiji
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan.
Faculty of Health and Sport Science, Ryutsu Keizai University, 120 Ryugasaki, Ibaraki 301-8555, Japan.
J Clin Biochem Nutr. 2018 May;62(3):254-258. doi: 10.3164/jcbn.17-103. Epub 2018 Mar 30.
Pulse pressure amplification (i.e., the ratio of peripheral to central pulse pressure) is a strong predictor of cardiovascular events. Circulating free fatty acid, which is a major cause of insulin resistance, has been reported to favorably be associated with pulse pressure amplification in the arm (from the aorta to brachial artery). We hypothesized that this paradoxical relationship depended on an evaluating site of pulse pressure amplification and investigated whether serum free fatty acid level is related to pulse pressure amplification in the arm or trunk (from the aorta to femoral artery) in overweight/obese men. In a cross-sectional study, 85 men participated, and regression analyses revealed that serum free fatty acid level was significantly and independently associated with pulse pressure amplification in the arm but not the trunk. In a longitudinal study, 33 men completed a 12-week lifestyle intervention that involved both exercise training and dietary modification. The lifestyle intervention-induced change in serum free fatty acid level was significantly correlated to that in pulse pressure amplification in the arm but not the trunk. These results support our hypothesis and suggest that pulse pressure amplification should be measured in the trunk instead of the arm in overweight/obese men to simplify its interpretation.
脉压放大（即外周脉压与中心脉压之比）是心血管事件的一个强有力的预测指标。循环游离脂肪酸是胰岛素抵抗的主要原因，据报道，它与手臂（从主动脉到肱动脉）的脉压放大呈正相关。我们推测这种矛盾的关系取决于脉压放大的评估部位，并研究了超重/肥胖男性血清游离脂肪酸水平与手臂或躯干（从主动脉到股动脉）脉压放大之间是否相关。在一项横断面研究中，85名男性参与其中，回归分析显示血清游离脂肪酸水平与手臂而非躯干的脉压放大显著且独立相关。在一项纵向研究中，33名男性完成了一项为期12周的生活方式干预，其中包括运动训练和饮食调整。生活方式干预引起的血清游离脂肪酸水平变化与手臂而非躯干的脉压放大变化显著相关。这些结果支持了我们的假设，并表明在超重/肥胖男性中，应在躯干而非手臂测量脉压放大，以简化其解读。
