Hoshi H, McKeehan W L
In Vitro Cell Dev Biol. 1985 Feb;21(2):125-8. doi: 10.1007/BF02620954.
Human hepatoma cells grow at high cell density in the absence of exogenous growth factors. At low cell density, two different hepatoma cell lines required a novel growth factor from brain tissue. A factor with similar physico-chemical properties in the concentrated medium from high density cultures completely substituted for the brain extract. The autogenous secretion of a novel liver cell growth factor that is concentrated in brain tissue may underlie in part the unregulated growth of hepatomas.
人类肝癌细胞在无外源性生长因子的情况下能在高细胞密度下生长。在低细胞密度时，两种不同的肝癌细胞系需要来自脑组织的一种新型生长因子。高密度培养浓缩培养基中具有相似物理化学性质的一种因子可完全替代脑提取物。一种在脑组织中浓缩的新型肝细胞生长因子的自身分泌可能部分是肝癌失控生长的基础。
