青霉烯醇类与抗生素对耐甲氧西林菌的协同抗菌活性

Synergistic antibacterial activity between penicillenols and antibiotics against methicillin-resistant .

作者信息

Li Shuihong, Mou Qianqian, Xu Xinya, Qi Shuhua, Leung Polly H M

机构信息

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, People's Republic of China.

Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong 999077, People's Republic of China.

出版信息

R Soc Open Sci. 2018 May 30;5(5):172466. doi: 10.1098/rsos.172466. eCollection 2018 May.

Penicillenol A2 (isolated from deep-sea fungus DFFSCS023) has good antibacterial activity against methicillin-sensitive and in combination with -lactam antibiotics it could significantly decrease methicillin-resistant (MRSA) survival, which provides a novel treatment consideration for MRSA-caused infections.