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深海来源微生物中生物活性次生代谢产物的研究进展。

Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms.

机构信息

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.

Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China.

出版信息

Mar Drugs. 2020 Dec 2;18(12):614. doi: 10.3390/md18120614.

DOI:10.3390/md18120614
PMID:33276592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7761599/
Abstract

Deep sea has an extreme environment which leads to biodiversity of microorganisms and their unique physical and biochemical mechanisms. Deep-sea derived microorganisms are more likely to produce novel bioactive substances with special mechanism of action for drug discovery. This article reviews secondary metabolites with biological activities such as anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory isolated from deep-sea fungi and bacteria during 2018-2020. Effective methods for screening and obtaining natural active compounds from deep-sea microorganisms are also summarized, including optimizing the culture conditions, using genome mining technology, biosynthesis and so on. The comprehensive application of these methods makes broader prospects for the development and application of deep sea microbial bioactive substances.

摘要

深海具有极端的环境条件，这导致了微生物的生物多样性及其独特的物理和生化机制。深海来源的微生物更有可能产生具有特殊作用机制的新型生物活性物质，可用于药物发现。本文综述了 2018-2020 年从深海真菌和细菌中分离得到的具有抗肿瘤、抗菌、抗病毒和抗炎等生物活性的次生代谢产物。还总结了从深海微生物中筛选和获得天然活性化合物的有效方法，包括优化培养条件、利用基因组挖掘技术、生物合成等。这些方法的综合应用为深海微生物生物活性物质的开发和应用提供了更广阔的前景。

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