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铜催化吲哚与亚磺酸钠的区域选择性硫醚化反应

Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates.

作者信息

Luo Xiaojun, Liu Qiang, Zhu Hongxia, Chen Huoji

机构信息

Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Shiliugang Road 13th, Guangzhou 510315, People's Republic of China.

School of Traditional Chinese Medicine, Southern Medical University, No.1023, South Shatai Road, Baiyun District, Guangzhou 510515, People's Republic of China.

出版信息

R Soc Open Sci. 2018 May 30;5(5):180170. doi: 10.1098/rsos.180170. eCollection 2018 May.

DOI:10.1098/rsos.180170
PMID:29892452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5990840/
Abstract

A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in ,-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance.

摘要

描述了一种在N，N-二甲基甲酰胺（DMF）中铜催化吲哚与亚磺酸钠的亚磺酰化反应，该反应能以良好至优异的产率得到3-亚磺酰基吲哚。在此过程中，DMF不仅作为溶剂，还作为还原剂。这种转化易于进行，反应条件温和，对官能团具有良好的耐受性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/b912b3ba0398/rsos180170-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/1fd973250e0b/rsos180170-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/b880659492db/rsos180170-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/b912b3ba0398/rsos180170-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/1fd973250e0b/rsos180170-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/b880659492db/rsos180170-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/166a/5990840/b912b3ba0398/rsos180170-g3.jpg

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