Rai Aditya, Prabhakar Neha Sharma, Kishor Kaushal, Singh Krishna Nand
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, India.
J Org Chem. 2024 Oct 18;89(20):15075-15082. doi: 10.1021/acs.joc.4c01819. Epub 2024 Oct 9.
A practical C3 sulfenylation of indoles has been accomplished using arenediazonium tosylates and sodium metabisulfite, with a key role of iodine/DMF combination in the reaction. The method involves scarce use of sodium metabisulfite as a divalent sulfur source and offers an array of structurally diverse 3-arylthioindoles in high yields under operationally simple transition-metal-free and mild conditions.
利用对甲苯磺酰重氮盐和焦亚硫酸钠实现了吲哚的实用C3亚磺酰化反应，碘/二甲基甲酰胺组合在该反应中起关键作用。该方法较少使用焦亚硫酸钠作为二价硫源，并且在操作简单、无过渡金属且温和的条件下，能高产率地提供一系列结构多样的3-芳硫基吲哚。
