Lasker N, Hopp L, Grossman S, Bamforth R, Aviv A
J Clin Invest. 1985 Jun;75(6):1813-20. doi: 10.1172/JCI111894.
Several reports indicate that erythrocytes (RBCs) from blacks and men have higher sodium concentrations than those from whites and women. One possible mechanism to explain this finding is a difference in the activity of Na+-K+-ATPase. To explore this possibility, we have studied the Na+ and K+ kinetics of RBC Na+-K+-ATPase and RBC Na+ and K+ concentrations in 37 normotensive blacks and whites, both males and females. The maximal initial reaction velocity (Vmax) values for RBC Na+-K+-ATPase were lower in blacks and men as compared with whites and women. Higher RBC Na+ levels were observed in blacks and males vs. whites and females. Significant inverse correlations were noted between the Na+-K+-ATPase activity and RBC Na+ concentrations. These findings indicate that cellular Na+ homeostasis is different in blacks and men as compared with whites and women. Since higher RBC Na+ concentrations have also been observed in patients with essential hypertension as compared with normotensive subjects, the higher intracellular Na+ concentrations in blacks and men may contribute to the greater predisposition of these groups to essential hypertension.
几份报告表明，黑人和男性的红细胞（RBCs）钠浓度高于白人和女性。解释这一发现的一种可能机制是钠钾ATP酶活性的差异。为了探究这种可能性，我们研究了37名血压正常的黑人和白人（包括男性和女性）红细胞钠钾ATP酶的钠和钾动力学以及红细胞钠和钾浓度。与白人和女性相比，黑人和男性红细胞钠钾ATP酶的最大初始反应速度（Vmax）值较低。与白人和女性相比，黑人和男性的红细胞钠水平较高。钠钾ATP酶活性与红细胞钠浓度之间存在显著的负相关。这些发现表明，与白人和女性相比，黑人和男性的细胞钠稳态有所不同。由于与血压正常的受试者相比，原发性高血压患者的红细胞钠浓度也较高，因此黑人和男性较高的细胞内钠浓度可能导致这些人群更容易患原发性高血压。
