M'Buyamba-Kabangu J R, Lijnen P, Groeseneken D, Staessen J, Lissens W, Goossens W, Fagard R, Amery A
J Hypertens. 1984 Dec;2(6):647-51. doi: 10.1097/00004872-198412000-00010.
Erythrocyte concentrations and fluxes of sodium and potassium were investigated in normal black and white male subjects. Erythrocyte sodium concentration was significantly elevated in blacks compared to whites. In single regression analysis erythrocyte sodium concentration was inversely related to the ouabain-sensitive 86Rb-uptake and to the frusemide-sensitive sodium efflux. After adjusting for race, only the relationship between the erythrocyte sodium concentration and the Na+, K+-ATpase pump activity persisted. The sodium-lithium countertransport system was also depressed in the black subjects. No significant difference was observed in erythrocyte potassium concentration between blacks and white. It is probable that, in blacks the decreased active influx of potassium through the sodium-potassium pump was to some extent counter balanced by a reduced efflux of this cationic mediated by the depressed cotransport system. There was no difference in cationic concentrations and fluxes of sodium and potassium between blacks bearing and not bearing haemoglobin S.
对正常黑人及白人男性受试者的红细胞钠、钾浓度及通量进行了研究。与白人相比，黑人的红细胞钠浓度显著升高。在单因素回归分析中，红细胞钠浓度与哇巴因敏感的86Rb摄取及呋塞米敏感的钠外流呈负相关。校正种族因素后，仅红细胞钠浓度与钠钾ATP酶泵活性之间的关系仍然存在。黑人受试者的钠-锂逆向转运系统也受到抑制。黑人和白人的红细胞钾浓度未观察到显著差异。在黑人中，通过钠钾泵的钾主动内流减少可能在一定程度上被由受抑制的协同转运系统介导的该阳离子外流减少所抵消。携带和不携带血红蛋白S的黑人之间，钠、钾阳离子浓度及通量没有差异。
