人类T细胞白血病/淋巴瘤病毒I感染及正常人B细胞的后续克隆。克隆细胞在无增殖增强情况下通过分化对重组白细胞介素2的直接反应性。
Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation.
作者信息
Tomita S, Ambrus J L, Volkman D J, Longo D L, Mitsuya H, Reitz M S, Fauci A S
出版信息
J Exp Med. 1985 Jul 1;162(1):393-8. doi: 10.1084/jem.162.1.393.
Abstract
A human T cell leukemia/lymphoma virus (HTLV)-I-infected B cell clone expressed Tac antigen on its cell surface and responded to recombinant interleukin 2 (IL-2) by increased production of IgM without any increase in proliferation. Anti-Tac antibody completely inhibited the IL-2-induced differentiation of this HTLV-I-infected B cell clone. This study demonstrates that HTLV-I can directly infect normal mature human B cells, and that the Tac antigen, which may be induced by infection with HTLV-I, is the functional receptor for IL-2-induced B cell differentiation. The availability of such cell lines and clones should provide useful tools to delineate precisely the differentiation step in the human B cell cycle.
摘要
一株人类T细胞白血病/淋巴瘤病毒（HTLV）-I感染的B细胞克隆在其细胞表面表达Tac抗原，并通过增加IgM的产生对重组白细胞介素2（IL-2）作出反应，而增殖没有任何增加。抗Tac抗体完全抑制了IL-2诱导的该HTLV-I感染的B细胞克隆的分化。本研究表明，HTLV-I可直接感染正常成熟的人类B细胞，并且可能由HTLV-I感染诱导产生的Tac抗原是IL-2诱导的B细胞分化的功能性受体。此类细胞系和克隆的可用性应为精确描绘人类B细胞周期中的分化步骤提供有用的工具。
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