Nazemi Azadeh, Higgins Shauna, Swift Reyna, In Gino, Miller Kimberly, Wysong Ashley
Medical Oncology.
Preventative Medicine, and.
Dermatol Surg. 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566.
Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management.
To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management.
A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines. This yielded 155 articles detailing 206 cases of porocarcinoma.
Eccrine porocarcinoma most often presents in elderly patients on the head and neck or lower limbs. Metastatic disease at presentation is not uncommon (22%). Primary tumor location is significantly correlated with presence of metastasis (p = .038). The most common treatment is excision followed by Mohs micrographic surgery (MMS), although the outcomes after MMS were superior to those after surgical excision.
This systematic review of individual patient data reveals that all patients should have a histological diagnosis with imaging considered for high-risk cases. Primary tumor location should also be considered in diagnostic and therapeutic decision-making. Although wide local excision (WLE) is currently the first-line treatment, MMS is becoming increasingly used, with evidence indicating improved outcomes as compared to those seen with WLE.
小汗腺汗孔癌（EPC）是一种罕见的皮肤肿瘤，具有较高的发病和死亡风险。由于其罕见性，关于其诊断、检查及治疗的数据较少。
汇总已报道的关于小汗腺汗孔癌的人口统计学、诊断、临床行为、治疗方式及患者预后的信息，以提供一个优化诊断和治疗的参考工具。
按照PRISMA指南，于1963年至2017年11月在PubMed上进行全面检索。共获得155篇详细描述206例汗孔癌病例的文章。
小汗腺汗孔癌最常发生于老年患者的头颈部或下肢。就诊时出现转移的情况并不少见（22%）。原发肿瘤部位与转移的发生显著相关（p = 0.038）。最常见的治疗方法是切除，随后进行莫氏显微外科手术（MMS），尽管MMS后的效果优于手术切除。
对个体患者数据的这项系统评价表明，所有患者均应进行组织学诊断，高危病例需考虑影像学检查。在诊断和治疗决策中也应考虑原发肿瘤部位。尽管广泛局部切除（WLE）目前是一线治疗方法，但MMS的应用越来越多，有证据表明与WLE相比，其效果有所改善。
