Feng Yinlu, Yin Zifei, Zhang Daniel, Srivastava Arun, Ling Chen
Department of Traditional Chinese Medicine, 401 Hospital of the Chinese People's Liberation Army, Qingdao, Shandong 266071, China.
Division of Cellular and Molecular Therapy, Department of Pediatrics, College of Medicine, University of Florida, Gainesville 32611, FL, United States.
Curr Protein Pept Sci. 2019;20(3):251-264. doi: 10.2174/1389203719666180612082432.
The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.
在过去二十年中，基因和细胞疗法在临床上取得的成功，以及我们在操控这些生物材料方面不断增强的能力，正为多种遗传性和后天性疾病带来新的治疗选择。将传统疗法与这一新兴领域相结合，是治疗那些以往被认为无法治愈疾病的一种有前景的策略。中药在中国已经发展了数千年，至今仍在人类健康中发挥着重要作用。作为中药的活性成分之一，蛋白质和肽长期以来一直吸引着研究人员的关注。最近，它们已被应用于基因和细胞疗法，从而产生了治疗癌症和非癌症疾病的有前景的新策略。本文对该领域进行了批判性综述，并对这一新兴前沿领域未来研究面临的挑战和新方向提出了见解。
