Department of Urology, China Medical University Hospital, Taichung, Taiwan, ROC.
Anticancer Res. 2011 Feb;31(2):745-9.
Multiple lines of evidence have implicated the Caveolin-1 (CAV1) gene in prostate cancer progression. CAV1 is located within the locus at 7q31-33 associated with prostate cancer aggressiveness, and was identified as being overexpressed in prostate tumors. Therefore, this study evaluated the relationship between the polymorphism of CAV1 and the risk of prostate cancer in Taiwan.
Two hundred and fifty patients with prostate cancer and five hundred age-matched healthy controls recruited were genotyped.
There were significant differences between prostate cancer and control groups in the distributions of their genotypes (p = 0.0004) and allelic frequencies (p = 4.9 × 10(-5)) in the CAV1 T29107A (rs7804372) polymorphisms.
This study provides evidence for the relationship of this variant of CAV1 and risk of prostate cancer which might merit further study as a genomic marker for early detection of prostate cancer.
多种证据表明 Cavin-1（CAV1）基因与前列腺癌的进展有关。CAV1 位于与前列腺癌侵袭性相关的 7q31-33 基因座内，并且在前列腺肿瘤中被鉴定为过度表达。因此，本研究评估了 CAV1 多态性与台湾地区前列腺癌风险之间的关系。
250 名前列腺癌患者和 500 名年龄匹配的健康对照者被进行基因分型。
CAV1 T29107A（rs7804372）多态性在基因型（p=0.0004）和等位基因频率（p=4.9×10（-5））分布方面，前列腺癌组与对照组之间存在显著差异。
本研究为 CAV1 这一变体与前列腺癌风险之间的关系提供了证据，这可能值得进一步研究，作为前列腺癌早期检测的基因组标记。
