Yang Kun, Dong Gaoxia, Tian Ying, Li Jian
Department of Obstetrics, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China.
Department of Obstetrics, Zhangqiu Maternity and Child Care Hospital, Jinan, Shandong 250200, P.R. China.
Exp Ther Med. 2018 Jul;16(1):167-170. doi: 10.3892/etm.2018.6173. Epub 2018 May 17.
Effects of compound Danshen injection combined with magnesium sulfate on serum myeloperoxidase (MPO) and hypersensitive C-reactive protein (hs-CRP) in patients with severe preeclampsia (PE) were investigated. Five hundred patients with severe PE were randomly divided into early-onset observation, early-onset control, late-onset observation and late-onset control groups. Control group was treated with magnesium sulfate, while patients in observation group were treated with magnesium sulfate combined with compound Danshen injection. Serum levels of MPO and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA) and turbidimetric assay. The effects of compound Danshen injection combined with magnesium sulfate on the above indexes were observed. Serum levels of MPO and hs-CRP significantly decreased in early-onset observation, late-onset observation, early-onset control and late-onset control groups after treatment (p<0.05). After treatment, levels of MPO and hs-CRP were significantly lower in early-onset observation group than in early-onset control group (p<0.05), and levels of MPO and hs-CRP were also significantly lower in late-onset observation group than in late-onset control group (p<0.05). Total effective rate of early-onset observation group and late-onset observation group were higher than that of early-onset control group and late-onset control group. Compound Danshen injection combined with magnesium sulfate achieved better treatment outcomes in the treatment of severe PE than magnesium sulfate alone. The combined treatment can effectively reduce the serum levels of MPO and hs-CRP.
探讨复方丹参注射液联合硫酸镁对重度子痫前期（PE）患者血清髓过氧化物酶（MPO）和超敏C反应蛋白（hs-CRP）的影响。将500例重度PE患者随机分为早发型观察组、早发型对照组、晚发型观察组和晚发型对照组。对照组采用硫酸镁治疗，观察组患者采用硫酸镁联合复方丹参注射液治疗。采用酶联免疫吸附测定法（ELISA）和比浊法测定血清MPO和hs-CRP水平。观察复方丹参注射液联合硫酸镁对上述指标的影响。治疗后，早发型观察组、晚发型观察组、早发型对照组和晚发型对照组血清MPO和hs-CRP水平均显著降低（p<0.05）。治疗后，早发型观察组MPO和hs-CRP水平显著低于早发型对照组（p<0.05），晚发型观察组MPO和hs-CRP水平也显著低于晚发型对照组（p<0.05）。早发型观察组和晚发型观察组的总有效率高于早发型对照组和晚发型对照组。复方丹参注射液联合硫酸镁治疗重度PE的效果优于单用硫酸镁。联合治疗可有效降低血清MPO和hs-CRP水平。
