Gergianaki Irini, Bertsias George
Rheumatology, Clinical Immunology and Allergy, University of Crete Faculty of Medicine, Iraklio, Greece.
Front Med (Lausanne). 2018 May 29;5:161. doi: 10.3389/fmed.2018.00161. eCollection 2018.
Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease that manifests a wide range of organ involvement. Traditionally, the diagnosis and management of SLE is provided at secondary and tertiary centers to ensure prompt initiation of treatment, adequate control of flares and prevention of irreversible organ damage. Notwithstanding, the role of primary care in SLE is also emerging as there are still significant unmet needs such as the diagnostic delay at the community level and the high burden of therapy- and disease-related comorbidities. In the present review, we summarize practical messages for primary care physicians and general practitioners (GPs) concerning early diagnosis and proper referral of patients with SLE. In addition, we discuss the main comorbidities complicating the disease course and the recommended preventative measures, and we also provide an update on the role and current educational needs of GPs regarding the disease.
系统性红斑狼疮（SLE）是一种复杂的慢性自身免疫性疾病，可累及多种器官。传统上，SLE的诊断和管理在二级和三级医疗中心进行，以确保及时开始治疗、充分控制病情发作并预防不可逆的器官损伤。尽管如此，基层医疗在SLE中的作用也日益凸显，因为仍存在一些未得到充分满足的需求，例如社区层面的诊断延迟以及治疗和疾病相关合并症的高负担。在本综述中，我们总结了针对基层医疗医生和全科医生（GPs）的实用信息，内容涉及SLE患者的早期诊断和正确转诊。此外，我们讨论了使疾病进程复杂化的主要合并症以及推荐的预防措施，并且还提供了关于全科医生在该疾病方面的作用和当前教育需求的最新情况。
