Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK.
Bioinformatics. 2018 Sep 15;34(18):3233-3234. doi: 10.1093/bioinformatics/bty321.
The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance. The curated Mycology Antifungal Resistance Database (MARDy) is a web-service of antifungal drug resistance mechanisms, including amino acid substitutions, tandem repeat sequences and genome ploidy. MARDy is implemented on a Linux, Apache, MySQL and PHP web development platform and includes a local installation of BLASTn of the database of curated genes.
MARDy can be accessed at http://www.mardy.net and is free to use. The complete database can be retrieved, ordered by organism, gene and drug. Missing or new mycological antifungal resistance data can be relayed to the development team through a contribute entry form. Updates and news will be publicized via a dedicated Twitter feed: @MARDYfungi.
抗真菌药物耐药性的增加是一个主要的全球人类健康问题，威胁着农业和粮食安全；为了解决这些问题，了解导致抗真菌耐药性的机制非常重要。经过精心整理的真菌抗真菌耐药数据库（MARDy）是一个抗真菌药物耐药机制的网络服务，包括氨基酸替换、串联重复序列和基因组倍性。MARDy 是在 Linux、Apache、MySQL 和 PHP 网络开发平台上实现的，包括对经过精心整理的基因数据库的本地 BLASTn 安装。
MARDy 可在 http://www.mardy.net 访问，并且可以免费使用。可以按生物体、基因和药物检索完整的数据库。可以通过“贡献条目”表单将缺失或新的真菌抗真菌耐药性数据转达给开发团队。更新和新闻将通过专用的 Twitter 饲料：@MARDYfungi 进行宣传。
