Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Maine Medical Center Research Institute, Scarborough, Maine.
Endocr Rev. 2018 Oct 1;39(5):701-718. doi: 10.1210/er.2018-00050.
Landmark advances in skeletal biology have arisen mainly from the identification of disease-causing mutations and the advent of rapid and selective gene-targeting technologies to phenocopy human disease in mice. Here, we discuss work on newly identified mechanisms controlling the remodeling of bone, communication of bone cells with cells of other lineages, and crosstalk between bone and vital organs as these relate to the therapeutic targeting of the skeleton.
骨骼生物学的重大进展主要源于致病突变的鉴定，以及快速、选择性的基因靶向技术的出现，从而在小鼠中模拟人类疾病。在这里，我们讨论了控制骨骼重塑、骨细胞与其他谱系细胞之间的通讯以及骨骼与重要器官之间的串扰的新发现机制的相关工作，这些工作与骨骼的治疗靶向有关。
