Department of Epidemiology, School of Public Health, and The Center for Human Growth and Development, University of Michigan, Ann Arbor, MI.
Medical School, Department of Medicine, The University of La Sabana, Colombia, Chía.
J Nutr. 2018 May 1;148(5):760-770. doi: 10.1093/jn/nxy029.
Iron deficiency (ID) in infancy is related to subsequent behavior problems. The effects of micronutrient status in middle childhood are uncertain.
The aim of the study was to examine the associations of micronutrient status biomarkers in middle childhood with externalizing and internalizing behavior problems in adolescence.
We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B-12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia. Behavior problems were assessed with the Youth Self-Report questionnaire after a median 6.2 y of follow-up. Mean problem score differences with 95% CIs were estimated between categories of micronutrient status biomarkers with the use of multivariable linear regression.
Mean ± SD externalizing and internalizing problems scores were 52.6 ± 9.6 and 53.8 ± 9.9, respectively. Among boys, middle-childhood ID, anemia, and low plasma vitamin B-12 were associated with 5.9 (95% CI: 1.0, 10.7), 6.6 (95% CI: 1.9, 11.3), and 2.7 (95% CI: 0.4, 4.9) units higher mean externalizing problems scores in adolescence, respectively-after adjustment for baseline age, time spent watching television or playing video games, mother's height, and socioeconomic status. Also in boys, ID was related to an adjusted 6.4 (95% CI: 1.2, 11.6) units higher mean internalizing problems score. There were no associations among girls. Other micronutrient status biomarkers were not associated with behavior problems.
ID, anemia, and low vitamin B-12 in middle childhood are related to behavior problems in adolescent boys.This study was registered at clinicaltrials.gov as NCT03297970.
婴儿缺铁（ID）与随后的行为问题有关。 目前尚不确定儿童中期微量营养素状况的影响。
本研究旨在研究儿童中期微量营养素状态生物标志物与青春期外化和内化行为问题之间的关系。
我们评估了 5-12 岁时 ID（铁蛋白<15μg/L）、贫血（血红蛋白<12.7g/dL）或血液中锌、维生素 A 和 B-12 以及叶酸的浓度是否与青春期时的外化或内化行为问题有关。1042 名来自哥伦比亚波哥大的学龄儿童在中位随访 6.2 年后使用青少年自我报告问卷评估行为问题。使用多变量线性回归估计 95%置信区间（CI）范围内不同微量营养素状态生物标志物类别之间的平均问题评分差异。
平均（±SD）外化和内化问题得分分别为 52.6±9.6 和 53.8±9.9。在男孩中，儿童中期 ID、贫血和低血浆维生素 B-12 与青春期时平均外化问题评分分别高 5.9（95%CI：1.0，10.7）、6.6（95%CI：1.9，11.3）和 2.7（95%CI：0.4，4.9）个单位有关，分别校正了基线年龄、看电视或玩视频游戏的时间、母亲身高和社会经济地位。同样，ID 与调整后的 6.4（95%CI：1.2，11.6）个单位的平均内化问题评分升高有关。女孩之间没有关联。其他微量营养素状态生物标志物与行为问题无关。
儿童中期 ID、贫血和低维生素 B-12 与青春期男孩的行为问题有关。本研究在 clinicaltrials.gov 上注册为 NCT03297970。
