Azupogo Fusta, Abizari Abdul-Razak, Osendarp Saskia J M, Feskens Edith J, Brouwer Inge D
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
Department of Nutritional Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Curr Dev Nutr. 2021 Jan 8;5(2):nzaa184. doi: 10.1093/cdn/nzaa184. eCollection 2021 Feb.
Investing in adolescent girls' nutrition is vital for health and for breaking the intergenerational cycle of malnutrition and deprivation, but limited knowledge on the type, timing, and efficacy of interventions delays progress. We describe the design of a 26-wk randomized placebo-controlled trial with multiple-micronutrient-fortified biscuits (MMBs) among adolescent girls in northeastern Ghana. Apparently healthy, premenarche (= 312) and postmenarche (= 309) girls (10-17 y) were randomly assigned to receive the following for 5 d/wk: ) MMBs (fortified with 11 vitamins and 7 minerals) or ) unfortified biscuits. Data included plasma micronutrient status, anthropometry, body composition, cognitive function, psychosocial health, fertility, dietary intake, and sociodemographic and socioeconomic covariates, complemented with in-depth interviews (= 30) and 4 focus group discussions. We hypothesized an increase in plasma ferritin and retinol-binding protein with a resultant increase in hemoglobin, cognition, vertical height, and psychosocial health. Our study seeks to investigate the efficacy and optimal timing of a multiple-micronutrient food intervention program for adolescent girls. The RCT was registered prospectively with the Netherlands Clinical Trials Register (NL7487).
投资于少女营养对于健康以及打破营养不良和贫困的代际循环至关重要，但对干预措施的类型、时机和效果了解有限，这延缓了进展。我们描述了在加纳东北部少女中开展的一项为期26周的随机安慰剂对照试验的设计，该试验使用多种微量营养素强化饼干（MMB）。表面健康的初潮前（=312名）和初潮后（=309名）女孩（10 - 17岁）被随机分配，每周5天接受以下处理：）MMB（强化了11种维生素和7种矿物质）或）未强化的饼干。数据包括血浆微量营养素状况、人体测量学、身体成分、认知功能、心理社会健康、生育能力、饮食摄入量以及社会人口统计学和社会经济协变量，并辅以深入访谈（=30次）和4次焦点小组讨论。我们假设血浆铁蛋白和视黄醇结合蛋白会增加，从而导致血红蛋白、认知、身高和心理社会健康状况改善。我们的研究旨在调查针对少女的多种微量营养素食物干预计划的效果和最佳时机。该随机对照试验已在荷兰临床试验注册中心（NL7487）进行了前瞻性注册。
