1 Johns Hopkins University School of Medicine, Baltimore, MD, USA.
2 VA Eastern Kansas Health Care System, Leavenworth, KS, USA.
J Aging Health. 2019 Sep;31(8):1398-1422. doi: 10.1177/0898264318781131. Epub 2018 Jun 14.
The aim of this study was to examine major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) diagnosed at age < 55 as predictors, and sex and race as potential moderators, of dementia and other forms of cognitive impairment. Veterans ( = 4,800) aged ⩾ 56 years were grouped by psychiatric history, sex, and race. Hierarchical and stepwise regression were employed to determine significant predictors. MDD and PTSD were associated with almost double the risk for developing dementia or cognitive impairment at age ⩾ 56. Sex, as a moderator, had small effects whereas race increased the risk almost twofold for Black veterans, given the presence of MDD history. MDD and PTSD act as significant risk factors for dementia and other forms of cognitive impairment, and Black veterans, given a history of MDD, may be at an increased risk. An important endeavor for future research is to examine how this risk may vary across dementia subtypes and related conditions.
本研究旨在探讨 55 岁以下被诊断为重度抑郁症（MDD）和创伤后应激障碍（PTSD）的患者作为痴呆症和其他形式认知障碍的预测因素，以及性别和种族作为潜在的调节因素。将年龄 ⩾ 56 岁的退伍军人（=4800）按精神病史、性别和种族分组。采用分层和逐步回归确定显著的预测因素。MDD 和 PTSD 与 56 岁及以上患者发生痴呆症或认知障碍的风险几乎增加了一倍。性别作为调节因素的影响较小，而种族则使 MDD 病史的黑人退伍军人的风险增加近两倍。MDD 和 PTSD 是痴呆症和其他形式认知障碍的重要危险因素，而有 MDD 病史的黑人退伍军人的风险可能会增加。未来研究的一个重要任务是研究这种风险如何在不同的痴呆症亚型和相关疾病中发生变化。
