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Claudin 蛋白在人胃癌组织与非瘤性黏膜中的表达谱差异。

Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa.

机构信息

Department of Gastroenterology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Department of Pathology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

出版信息

Mol Med Rep. 2018 Aug;18(2):1271-1278. doi: 10.3892/mmr.2018.9122. Epub 2018 Jun 1.

DOI:10.3892/mmr.2018.9122
PMID:29901188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6072183/
Abstract

Numerous genetic alterations associated with cancer progression have the potential to serve as biomarkers for the early diagnosis of cancer. Numerous studies have suggested that claudin proteins, which are the primary components of tight junction structures, are associated with the regulation of cell polarity and cell differentiation. To investigate the expression profiles of the tight junction proteins claudin‑2, ‑5, ‑7 and ‑8 in gastric carcinoma, immunohistochemical analysis, western blotting and reverse transcription‑quantitative polymerase chain reaction analysis was used to detect the expression profiles of these claudin proteins in gastric carcinoma tissues and in homologous non‑neoplastic mucosal tissues. According to the present study, the expression levels of claudin‑7 and claudin‑8 were downregulated, while the expression of claudin‑5 was upregulated in gastric carcinoma tissues compared with in non‑neoplastic mucosal tissues. Additionally, no notable difference was observed between claudin‑2 expression in gastric carcinoma tissues and non‑neoplastic mucosae. Correlations between claudin‑7 and ‑8 expression and lymphatic metastasis in gastric carcinoma tissues were additionally reported. In summary, the present study revealed the distinct expression profiles of claudin‑5, ‑7 and ‑8 in non‑neoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma, and had predictive value for the metastasis and survival of patients with gastric carcinoma.

摘要

许多与癌症进展相关的遗传改变有可能作为癌症早期诊断的生物标志物。许多研究表明，紧密连接结构的主要组成部分紧密连接蛋白与细胞极性和细胞分化的调节有关。为了研究紧密连接蛋白 claudin-2、-5、-7 和 -8 在胃癌中的表达谱，采用免疫组织化学分析、western blot 分析和逆转录-定量聚合酶链反应分析检测胃癌组织和同源非肿瘤黏膜组织中这些紧密连接蛋白的表达谱。根据本研究，claudin-7 和 claudin-8 的表达水平下调，而 claudin-5 的表达在胃癌组织中上调与非肿瘤黏膜组织相比。此外，在胃癌组织和非肿瘤黏膜中 claudin-2 的表达无明显差异。此外，还报道了 claudin-7 和 -8 在胃癌组织中的表达与淋巴转移之间的相关性。综上所述，本研究揭示了 claudin-5、-7 和 -8 在非肿瘤黏膜组织和胃癌组织中的不同表达谱。此外，这些紧密连接蛋白的表达与胃癌患者的转移进展和预后高度相关，对胃癌患者的转移和生存具有预测价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/626970e34990/MMR-18-02-1271-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/79b353a3e02c/MMR-18-02-1271-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/c94eadd0561c/MMR-18-02-1271-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/3c33f42f13f7/MMR-18-02-1271-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/626970e34990/MMR-18-02-1271-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/79b353a3e02c/MMR-18-02-1271-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/c94eadd0561c/MMR-18-02-1271-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/3c33f42f13f7/MMR-18-02-1271-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6271/6072183/626970e34990/MMR-18-02-1271-g03.jpg

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