Huang Yansong, Zhang Yuan, Lin Zhexuan, Han Ming, Cheng Hongqiu
Second Affiliated Hospital Bio-analytical Laboratory, Shantou University Medical College, Shantou, China.
Medicine (Baltimore). 2018 Jun;97(24):e11137. doi: 10.1097/MD.0000000000011137.
Copper homeostasis can be altered by inflammation. This study aimed to investigate the alteration of serum copper homeostasis and to explore its clinical significance in patients with chronic hepatitis B (CHB).Thirty-two patients with CHB and 10 aged- and sex-matched healthy controls were recruited. Analyses included serum levels of total copper (TCu), copper ions (Cu), small molecule copper (SMC), ceruloplasmin (CP), Cu/Zn superoxide dismutase 1 (SOD1), urinary copper, and the activities of serum CP and SOD1.The serum TCu and urinary copper levels in patients with CHB were significantly higher than the controls (P = .04 and .003), while the serum Cu was lower than the controls (P = .0002). CP and SOD1 activities in the serum were significantly lower in patients with CHB compared to controls (P = .005) despite higher serum concentrations. In addition, serum alanine aminotransferase inversely correlated with serum CP activity (P = .0318, r = -0.4065).Serum copper homeostasis was altered in this cohort of patients with CHB. The results suggest increased oxidative stress and impaired antioxidant capability in patients with CHB, in addition to necroinflammation. These results may provide novel insights into the diagnosis and treatment of patients with CHB.
铜稳态可因炎症而改变。本研究旨在调查慢性乙型肝炎（CHB）患者血清铜稳态的变化，并探讨其临床意义。招募了32例CHB患者和10名年龄及性别匹配的健康对照者。分析指标包括血清总铜（TCu）、铜离子（Cu）、小分子铜（SMC）、铜蓝蛋白（CP）、铜/锌超氧化物歧化酶1（SOD1）、尿铜，以及血清CP和SOD1的活性。CHB患者的血清TCu和尿铜水平显著高于对照组（P = 0.04和0.003），而血清Cu低于对照组（P = 0.0002）。尽管血清浓度较高，但CHB患者血清中的CP和SOD1活性显著低于对照组（P = 0.005）。此外，血清丙氨酸氨基转移酶与血清CP活性呈负相关（P = 0.0318，r = -0.4065）。该队列CHB患者的血清铜稳态发生了改变。结果表明，CHB患者除坏死性炎症外，氧化应激增加且抗氧化能力受损。这些结果可能为CHB患者的诊断和治疗提供新的见解。
