慢性乙型肝炎中的氧化应激——最新进展
Oxidative Stress in Chronic Hepatitis B-An Update.
作者信息
Popa Gabriela Loredana, Popa Mircea Ioan
机构信息
Department of Microbiology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
"Cantacuzino" National Military Medical Institute for Research and Development, 011233 Bucharest, Romania.
出版信息
Microorganisms. 2022 Jun 21;10(7):1265. doi: 10.3390/microorganisms10071265.
Abstract
In recent years, the role of oxidative stress has been investigated in an increasing number of infections. There is a close link between the inflammation that accompanies infections and oxidative stress. Excessive reactive oxygen species induce harmful effects on cell components, including lipids, proteins, and nucleic acids. A growing body of evidence attests to the role of oxidative stress in the pathogenesis of viral liver infections, especially in hepatitis C virus (HCV) infection. Regarding hepatitis B virus (HBV) infection, the data are limited, but important progress has been achieved in recent years. This review presents the latest advances pertaining to the role of the oxidative stress byproducts in the pathogenesis of chronic hepatitis B, constituting a source of potential new markers for the evaluation and monitoring of patients with chronic hepatitis B.
摘要
近年来，氧化应激在越来越多感染中的作用得到了研究。感染伴随的炎症与氧化应激之间存在密切联系。过量的活性氧对细胞成分（包括脂质、蛋白质和核酸）产生有害影响。越来越多的证据证明氧化应激在病毒性肝感染发病机制中的作用，尤其是在丙型肝炎病毒（HCV）感染中。关于乙型肝炎病毒（HBV）感染，数据有限，但近年来已取得重要进展。本综述介绍了氧化应激副产物在慢性乙型肝炎发病机制中的作用的最新进展，构成了评估和监测慢性乙型肝炎患者的潜在新标志物来源。
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