Chick Gregoire, Victor Jan, Poujade Thibault, Hollevoet Nadine
Department of Hand Surgery and Peripheral Nerve Surgery, Hôpital de la Tour, Geneva, Switzerland.
Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Gent, Belgium.
J Neurol Surg A Cent Eur Neurosurg. 2018 Sep;79(5):408-415. doi: 10.1055/s-0038-1655548. Epub 2018 Jun 14.
To identify the frequency of reports of sporadic schwannomatosis, the types of patients affected, and the nerves affected.
We identified all case reports and case series that reported on patients with sporadic schwannomatosis according to established criteria.
The initial search yielded 1,597 studies, of which 15 were included. A total of 38 of 55 individuals met the inclusion criteria. The mean age of the patients was 48 years; 41% were male. Thirty-three patients had peripheral nerve tumors, and 17 had spinal tumors. Twelve had tumors in both locations. Tumor distribution was unilateral in 25 of 30 cases (83.3%) and segmental (limited to one limb or five or fewer contiguous segments of the spine) in 28 of 38 cases (73.7%).
This systematic review quantified the number of individuals who meet the criteria for sporadic schwannomatosis and better described this population to facilitate the classification of neurofibromatosis in regard to the 2005 consensus statement. Unilateral or segmental distribution of nerve tumors are key aspects when dealing with multiple noncutaneous schwannomas without involvement of the vestibular nerve.
确定散发性神经鞘瘤病报告的频率、受影响患者的类型以及受影响的神经。
我们根据既定标准确定了所有报告散发性神经鞘瘤病患者的病例报告和病例系列。
初步检索得到1597项研究，其中15项被纳入。55名个体中有38名符合纳入标准。患者的平均年龄为48岁；41%为男性。33例患者有周围神经肿瘤，17例有脊柱肿瘤。12例在两个部位均有肿瘤。30例中有25例（83.3%）肿瘤分布为单侧，38例中有28例（73.7%）为节段性（局限于一个肢体或脊柱的五个或更少连续节段）。
本系统评价对符合散发性神经鞘瘤病标准的个体数量进行了量化，并更好地描述了这一人群，以促进根据2005年共识声明对神经纤维瘤病进行分类。在处理多个非皮肤性神经鞘瘤且不累及前庭神经时，神经肿瘤的单侧或节段性分布是关键方面。
