Li Y R, Ding X, Wang C Y, Han D M
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery(Capital Medical University), Ministry of Education, Beijing 100730, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Jun 7;53(6):419-423. doi: 10.3760/cma.j.issn.1673-0860.2018.06.005.
To investigate the sleep-related deglutition in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with sleep stage and cortical arousals. From December 2015 to September 2017, simultaneous polysomnography and pharyngeal pressure monitoring were performed in 23 adult patients with OSAHS, Mann-Whitney test were employed to analyze the following parameters: (1) the relationship between arousal and deglutition; (2) the effect of sleep stage on deglutition; (3) The relationship between the frequency of deglutition and the severity of OSAHS. The subjects in this study aged (43±12) years, and the mean apnea-hypopnea index (AHI) was (49.2±27.7) times/hour. A total of 1 382 deglutition were recorded during sleep, with a median of 9.2[5.8, 13.8]times/person. There was a positive correlation between deglutition frequency and AHI(=0.570, =0.005) and negatively correlated with oxygen saturation (=-0.639, =0.001). The majority of the deglutition (73.7%) occurred after the respiratory event and in association with respiratory arousal. Deglutition occurred more in Non-rapid eye movement sleep stage 1 (N1) than N2, N3 and REM sleep (=-3.680, <0.001; =-2.746, =0.006; =- 3.490, <0.001). The occurrence of deglutition in patients with OSAHS is associated with cortical arousals. Deglutition frequency increased with the severity of apnea and affected by sleep staging.
探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者睡眠相关吞咽情况及其与睡眠阶段和皮层觉醒的相关性。2015年12月至2017年9月，对23例成年OSAHS患者同时进行多导睡眠图和咽部压力监测，采用曼-惠特尼检验分析以下参数：（1）觉醒与吞咽的关系；（2）睡眠阶段对吞咽的影响；（3）吞咽频率与OSAHS严重程度的关系。本研究对象年龄为（43±12）岁，平均呼吸暂停低通气指数（AHI）为（49.2±27.7）次/小时。睡眠期间共记录到1382次吞咽，中位数为9.2[5.8，13.8]次/人。吞咽频率与AHI呈正相关（r = 0.570，P = 0.005），与血氧饱和度呈负相关（r = -0.639，P = 0.001）。大多数吞咽（73.7%）发生在呼吸事件之后并与呼吸觉醒相关。吞咽在非快速眼动睡眠1期（N1）比N2、N3和快速眼动睡眠期更多见（P = -3.680，P < 0.001；P = -2.746，P = 0.006；P = -3.490，P < 0.001）。OSAHS患者吞咽的发生与皮层觉醒有关。吞咽频率随呼吸暂停严重程度增加而增加，并受睡眠分期影响。
