Wang Lijuan, Sun Jing, Huang Jian, Li Hong, Li Jin, Tang Yanbin, Piao Wei, Chen Di, Huo Junsheng
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Wei Sheng Yan Jiu. 2016 Nov;45(6):911-937.
To assess the iron status among boarding school students in a cross-sectional study performed in 9 provinces which were Beijing, Guangdong, Guangxi, Zhejiang, Tianjin, Ningxia, Sichuan, Shanghai and Shandong provinces.
A multi-stage cluster sampling survey on iron status of first-year junior high school students in rural boarding school in 9 provinces was used. Iron status was defined utilising biochemical indicators. Hemoglobin was measured by cyanmethemoglobin method. WS/T441-2013's hemoglobin thresholds used to define anemia. Immunoturbidimetric assay was used as analytical method for serum ferritin( SF), Serum soluble transferrin receptor( sTfR) and high sensitive C-reactive protein( hsCRP). BI was calculated by SF andsTfR. Storage iron depletion( SID) was defined as low SF( SF < 25 ng/mL) and low sTfR( sTfR < 4. 4 mg/L) without anemia. Iron deficient erythropoiesis( IDE) was defined as low SF( SF < 25 ng/mL) and high sTfR( sTfR > 4. 4 mg/L) without anemia. Iron deficiency anemia( IDA) was defined as low SF( SF < 25 ng/mL) with anemia. Subjects with indication of inflammation( hsCRP > 5 mg/L) were excluded from the analyses.
A total of 1263 adolescents aged 10-18 years( 696 boys and 567 girls) were involved. The levels of hemoglobin, serum ferritin, sTfR and BI concentration were( 144. 6 ± 13. 2) g/L, 52. 2 ng/mL, 3. 34 mg/L and( 6. 72 ± 2. 61) mg/kg for students, respectively. The overall prevalence of anemia was 4. 8%. The percentage of iron deficiency was 10. 5%, significantly higher in girls compared with boys. The overall percentage of SID, IDE and IDA was 6. 6%, 2. 5% and 1. 4%, respectively, with significant differences between boys and girls.
To ensure adequate iron stores, specific attention should be given to girls to ensure that their dietary intake of iron is adequate.
在一项对北京、广东、广西、浙江、天津、宁夏、四川、上海和山东9个省份进行的横断面研究中，评估寄宿制学校学生的铁营养状况。
采用多阶段整群抽样调查9个省份农村寄宿制初中一年级学生的铁营养状况。利用生化指标定义铁营养状况。血红蛋白采用氰化高铁血红蛋白法测定。采用WS/T441 - 2013的血红蛋白阈值定义贫血。采用免疫比浊法分析血清铁蛋白（SF）、血清可溶性转铁蛋白受体（sTfR）和高敏C反应蛋白（hsCRP）。通过SF和sTfR计算转铁蛋白受体指数（BI）。储存铁缺乏（SID）定义为SF低（SF < 25 ng/mL）且sTfR低（sTfR < 4.4 mg/L）且无贫血。缺铁性红细胞生成（IDE）定义为SF低（SF < 25 ng/mL）且sTfR高（sTfR > 4.4 mg/L）且无贫血。缺铁性贫血（IDA）定义为SF低（SF < 25 ng/mL）且伴有贫血。有炎症迹象（hsCRP > 5 mg/L）的受试者被排除在分析之外。
共纳入1263名10 - 18岁青少年（696名男孩和567名女孩）。学生的血红蛋白、血清铁蛋白、sTfR和BI浓度水平分别为（144.6 ± 13.2）g/L、52.2 ng/mL、3.34 mg/L和（6.72 ± 2.61）mg/kg。贫血的总体患病率为4.8%。铁缺乏的百分比为10.5%，女孩显著高于男孩。SID、IDE和IDA的总体百分比分别为6.6%、2.5%和1.4%，男孩和女孩之间存在显著差异。
为确保充足的铁储存，应特别关注女孩，以确保其膳食中铁摄入量充足。
