National Research Institute on Food and Nutrition, Rome, Italy.
Eur J Clin Nutr. 2011 Mar;65(3):340-9. doi: 10.1038/ejcn.2010.279. Epub 2011 Jan 19.
BACKGROUND/OBJECTIVES: To assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities.
SUBJECTS/METHODS: Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF<15 μg/l). Iron deficiency (ID) was defined as high-soluble transferrin receptor (sTfR>8.5 mg/l) plus iron depletion. Iron deficiency anaemia (IDA) was defined as ID with haemoglobin (Hb) below the WHO cutoff for age and sex: 12.0 g/dl for girls and for boys aged 12.5-14.99 years and 13.0 g/dl for boys aged ≥15 years. Enzyme linked immunosorbent assay was used as analytical method for SF, sTfR and C-reactive protein (CRP). Subjects with indication of inflammation (CRP >5 mg/l) were excluded from the analyses. A total of 940 adolescents aged 12.5-17.49 years (438 boys and 502 girls) were involved.
The percentage of iron depletion was 17.6%, significantly higher in girls (21.0%) compared with boys (13.8%). The overall percentage of ID and IDA was 4.7 and 1.3%, respectively, with no significant differences between boys and girls. A correlation was observed between log (SF) and Hb (r = 0.36, P < 0.01), and between log (sTfR) and mean corpuscular haemoglobin (r = -0.30, P < 0.01). Iron body stores were estimated on the basis of log (sTfR/SF). A higher percentage of negative values of body iron was recorded in girls (16.5%) with respect to boys (8.3%), and body iron values tended to increase with age in boys, whereas the values remained stable in girls.
To ensure adequate iron stores, specific attention should be given to girls at European level to ensure that their dietary intake of iron is adequate.
背景/目的：通过在 10 个欧洲城市进行的横断面研究，利用生化指标评估欧洲青少年的铁状况。
研究对象/方法：利用生化指标定义铁状态。铁缺乏定义为血清铁蛋白（SF）<15μg/l。缺铁（ID）定义为高可溶性转铁蛋白受体（sTfR）>8.5mg/l 加铁缺乏。缺铁性贫血（IDA）定义为 ID 伴血红蛋白（Hb）低于世卫组织按年龄和性别划分的临界值：女孩为 12.0g/dl，年龄为 12.5-14.99 岁的男孩和年龄为≥15 岁的男孩为 13.0g/dl。酶联免疫吸附测定法用于 SF、sTfR 和 C 反应蛋白（CRP）的分析方法。有炎症迹象（CRP>5mg/l）的受试者被排除在分析之外。共有 940 名年龄在 12.5-17.49 岁的青少年（438 名男孩和 502 名女孩）参与了研究。
铁缺乏的百分比为 17.6%，女孩（21.0%）明显高于男孩（13.8%）。总的 ID 和 IDA 百分比分别为 4.7%和 1.3%，男孩和女孩之间无显著差异。观察到 log（SF）与 Hb（r = 0.36，P<0.01）和 log（sTfR）与平均红细胞血红蛋白（r =-0.30，P<0.01）之间存在相关性。根据 log（sTfR/SF）估计铁体储存量。与男孩（8.3%）相比，女孩（16.5%）记录到更多的铁体负值，并且男孩的铁体值随着年龄的增长而增加，而女孩的铁体值保持稳定。
为确保充足的铁储存，欧洲层面应特别关注女孩，确保其铁摄入量充足。
