Wei Jingyan, Zhang Huaqi, Wang Yan, Li Changgui, Ma Aiguo
Department of Nutrition and Food Hygiene, College of Public Health, Qingdao University, Qingdao 266023, China.
Wei Sheng Yan Jiu. 2017 Mar;46(2):232-236.
To analyze the relationship between serum ferritin(SF) level and high sensitive C reactive protein( hs-CRP) in men and the risk of gout.
We chosed 600 male patients diagnosed with gout as gout group, 600 male patients with hyperuricemia were diagnosed as hyperuricemia group, and randomly selected 600 cases of the same period of male health examination as the control group. The detection information of physical examination and related indicators of three groups were collected, such as height, weight, serum ferritin, high sensitive C reactive protein, uric acid( UA), fasting blood glucose( FPG), triglyceride(TG), total cholesterol( TC) and so on.
Serum ferritin( SF) higher than that of hyperuricemia group 114. 45 μg/L( P<0. 05)and the control group 76. 02 μg/L( P<0. 05), while the level of hs-CRP in gout patients up to 0. 3 mg/dL, was significantly higher than that 0. 13 mg/dL in hyperuricemia group and 0. 09 mg/dL in control group( all P<0. 05). After adjusting for BMI, TG, TC, FPG and UA five confounding factors, SF was positively correlated with hs-CRP levels in the hyperuricemia group and the gout group, while there was no association between SF and hs-CRP levels in the control group. The multivariate logistic regression analysis showed that SF( ≥ 69. 01 μg/L) had significantly increased risk of HUA, after adjusting for BMI, TG, TC, FPG and UA five confounding factors, the high level of SF( ≥155. 78μg/L) had significantly increased risk of gout, with OR of 2. 678( 95% CI 1. 484-4. 833), and higher levels of hs-CRP( > 0. 9 mg/dL) was also a risk factor of gout, with OR of 3. 104( 95% CI 1. 727-5. 580). However, SF and hs-CRP were not risk factors of hyperuricemia.
Serum ferritin level and high sensitive C reactive protein levels are significantly elevated in patients with gout. It is revealed that hs-CRP, SF may be involved in the pathogenesis of gout patients.
分析男性血清铁蛋白（SF）水平与高敏C反应蛋白（hs-CRP）及痛风发病风险的关系。
选取600例确诊为痛风的男性患者作为痛风组，600例高尿酸血症男性患者作为高尿酸血症组，并随机抽取同期600例男性健康体检者作为对照组。收集三组的体格检查及相关指标检测信息，如身高、体重、血清铁蛋白、高敏C反应蛋白、尿酸（UA）、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）等。
痛风组血清铁蛋白（SF）高于高尿酸血症组114.45μg/L（P<0.05）及对照组76.02μg/L（P<0.05），而痛风患者hs-CRP水平达0.3mg/dL，显著高于高尿酸血症组的0.13mg/dL及对照组的0.09mg/dL（均P<0.05）。校正BMI、TG、TC、FPG及UA五个混杂因素后，高尿酸血症组和痛风组中SF与hs-CRP水平呈正相关，而对照组中SF与hs-CRP水平无关联。多因素logistic回归分析显示，校正BMI、TG、TC、FPG及UA五个混杂因素后，SF（≥69.01μg/L）使高尿酸血症发病风险显著增加，SF高水平（≥155.78μg/L）使痛风发病风险显著增加，OR为2.678（95%CI 1.484-4.833），hs-CRP高水平（>0.9mg/dL）也是痛风的危险因素，OR为3.104（95%CI 1.727-5.580）。然而，SF和hs-CRP不是高尿酸血症的危险因素。
痛风患者血清铁蛋白水平和高敏C反应蛋白水平显著升高。提示hs-CRP、SF可能参与痛风患者的发病机制。
