趋化因子受体 3（ACKR3）在正常发育和生理中的新兴作用。
Emerging roles of atypical chemokine receptor 3 (ACKR3) in normal development and physiology.
机构信息
Department of Cell Biology and Physiology, 111 MasonFarm Rd., 6312B MBRB CB# 7545, The University of North Carolina, Chapel Hill, NC 27599-7545, USA.
Department of Cell Biology and Physiology, 111 MasonFarm Rd., 6312B MBRB CB# 7545, The University of North Carolina, Chapel Hill, NC 27599-7545, USA.
出版信息
Cytokine. 2018 Sep;109:17-23. doi: 10.1016/j.cyto.2018.02.024.
Abstract
The discovery that atypical chemokine receptors (ACKRs) can initiate alternative signaling pathways rather than classical G-protein coupled receptor (GPCR) signaling has changed the paradigm of chemokine receptors and their roles in modulating chemotactic responses. The ACKR family has grown over the years, with discovery of new functions and roles in a variety of pathophysiological conditions. However, the extent to which these receptors regulate normal physiology is still continuously expanding. In particular, atypical chemokine receptor 3 (ACKR3) has proven to be an important receptor in mediating normal biological functions, including cardiac development and migration of cortical neurons. In this review, we illustrate the versatile and intriguing role of ACKR3 in physiology.
摘要
趋化因子受体（ACKR）可启动替代信号通路，而不是经典的 G 蛋白偶联受体（GPCR）信号，这一发现改变了趋化因子受体及其在调节趋化反应中的作用模式。多年来，ACKR 家族不断发展，在各种病理生理条件下发现了新的功能和作用。然而，这些受体在多大程度上调节正常生理机能仍在不断扩大。特别是，非典型趋化因子受体 3（ACKR3）已被证明是介导正常生物学功能的重要受体，包括心脏发育和皮质神经元的迁移。在这篇综述中，我们说明了 ACKR3 在生理学中的多功能和有趣作用。
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Br J Pharmacol. 2018 May;175(9):1419-1438. doi: 10.1111/bph.14132. Epub 2018 Mar 23.
2
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