University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Nat Rev Microbiol. 2018 Aug;16(8):457-470. doi: 10.1038/s41579-018-0036-x.
The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.
肠道黏膜屏障由上皮细胞组成，这些上皮细胞受到覆盖其上的宿主分泌的黏液层的保护，其功能是抵御致病和非致病微生物的第一道防线。一些微生物已经进化出了在黏膜屏障中生存或规避它以建立感染的策略。在这篇综述中，我们讨论了共生微生物与肠道黏膜屏障之间复杂相互作用的现有知识状态，并讨论了致病菌利用不同的上皮细胞谱系或破坏黏液层来建立感染的策略，以及黏液产生缺陷在慢性疾病中的作用。
