Abhimanyu Kedar Kalyani, Ravindra Chaudhari Sanjay, Avanapu Rao Srinivasa
Department of Pharmacognosy, Progressive Education Society's Modern College of Pharmacy, Sector-21, Yamunanagar Nigdi, Pune 411044, Maharashtra, India.
Jawaharlal Nehru Technological University (JNTU), Hyderabad, Andra Pradesh 500072, India.
Data Brief. 2018 May 2;18:1839-1846. doi: 10.1016/j.dib.2018.04.124. eCollection 2018 Jun.
The data existing in this article are associated to the antidiabetic activity of ethyl acetate extract of Wall barks (EAPR) in streptozotocin (STZ) induced diabetic rats at a dose of 250 & 500 mg/kg by oral route for 21 days. The phytochemical screening of the extract was carried out by gas chromatography and mass spectrometry. Diabetes was induced by streptozotocin (50 mg/kg; i.p), EAPR (250 & 500 mg/kg; b.wt) and standard Insulin (6 IU/animal; subcutaneous; o.i.d) were administered to the diabetic rats. Body weight and blood glucose were estimated weekly. Cholesterol, SOD and CAT were estimated in the blood serum on 21 days of the investigation period. Oral administration of EAPR (500 mg/kg) significant rises in the body weight, decrease in the blood glucose and total cholesterol and restore function of SOD and CAT enzymes ( < 0.05). Current data were also supported by histological study, necrosis was observed in the diabetic rat pancreas; however, necrosis was less observable in treated groups. These findings reveal that an ethyl acetate extract of Wall barks shows antihyperglycemic, anti-cholesterolemic, antioxidant and improved the cell density of β-cells of islets of Langerhans in diabetic rats.
本文中的数据与Wall树皮乙酸乙酯提取物（EAPR）对链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病活性相关，给药剂量为250和500mg/kg，经口服途径给药21天。通过气相色谱和质谱对提取物进行了植物化学筛选。通过腹腔注射链脲佐菌素（50mg/kg）诱导糖尿病，对糖尿病大鼠给予EAPR（250和500mg/kg；体重）和标准胰岛素（6IU/动物；皮下注射；每日一次）。每周估计体重和血糖。在研究期的第21天测定血清中的胆固醇、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。口服EAPR（500mg/kg）可显著增加体重、降低血糖和总胆固醇，并恢复SOD和CAT酶的功能（P<0.05）。组织学研究也支持了当前的数据，在糖尿病大鼠胰腺中观察到坏死；然而，在治疗组中坏死不太明显。这些发现表明，Wall树皮乙酸乙酯提取物具有降血糖、抗胆固醇、抗氧化作用，并改善了糖尿病大鼠胰岛β细胞的细胞密度。
