Stinchcombe T, Clough W
Biochemistry. 1985 Apr 9;24(8):2027-33. doi: 10.1021/bi00329a034.
Epstein-Barr (EB) virus induces a new pyrimidine deoxynucleoside kinase [thymidine kinase (dTk)] activity in Raji B lymphocyte cells after superinfection. This dTk activity is also present in small amounts in the HR-1 virus-producer cell line and in larger amounts in the B95-8 virus-producer line. The dTk activity induced by EB virus coelutes from DEAE-cellulose columns with deoxycytidine kinase (dCk) activity and elutes as a broad peak well separated from the large peaks of cellular dTk and dCk activities. This EB virus-induced pyrimidine deoxynucleoside kinase activity from HR-1 cells differs from cellular kinases in most basic biochemical properties but shares certain properties with the herpes simplex virus dTk.
爱泼斯坦-巴尔（EB）病毒在超感染后可诱导拉吉B淋巴细胞产生一种新的嘧啶脱氧核苷激酶[胸苷激酶（dTk）]活性。这种dTk活性在HR-1病毒产生细胞系中也有少量存在，而在B95-8病毒产生细胞系中的含量更高。EB病毒诱导的dTk活性与脱氧胞苷激酶（dCk）活性从DEAE-纤维素柱上共洗脱，洗脱时呈现为一个宽峰，与细胞dTk和dCk活性的大峰明显分开。来自HR-1细胞的这种EB病毒诱导的嘧啶脱氧核苷激酶活性在大多数基本生化特性上与细胞激酶不同，但与单纯疱疹病毒dTk具有某些共同特性。
