Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States of America.
Department of Cardiology, Shanghai Ruijin Hospital, Shanghai, China.
PLoS One. 2018 Jun 15;13(6):e0196916. doi: 10.1371/journal.pone.0196916. eCollection 2018.
Dispersion of ventricular repolarization due to abnormal activation contributes to the susceptibility to cardiac arrhythmias. However, the global pattern of repolarization is difficult to assess clinically. Activation recovery interval (ARI) has been used to understand the properties of ventricular repolarization. In this study, we developed an ARI imaging technique to noninvasively reconstruct three-dimensional (3D) ARI maps in 10 premature ventricular contraction (PVC) patients and evaluated the results with the endocardial ARI maps recorded by a clinical navigation system (CARTO). From the analysis results of a total of 100 PVC beats in 10 patients, the average correlation coefficient is 0.86±0.05 and the average relative error is 0.06±0.03. The average localization error is 4.5±2.3 mm between the longest ARI sites in 3D ARI maps and those in CARTO endocardial ARI maps. The present results suggest that ARI imaging could serve as an alternative of evaluating global pattern of ventricular repolarization noninvasively and could assist in the future investigation of the relationship between global repolarization dispersion and the susceptibility to cardiac arrhythmias.
心室复极的离散性是由于异常激活导致的，这会增加心脏心律失常的易感性。然而，整体复极模式在临床上很难评估。激活后恢复间期（ARI）已被用于了解心室复极的特性。在这项研究中，我们开发了一种 ARI 成像技术，以非侵入性地重建 10 名室性早搏（PVC）患者的三维（3D）ARI 图谱，并将结果与临床导航系统（CARTO）记录的心内膜 ARI 图谱进行比较。通过对 10 名患者的 100 个 PVC 搏动的分析结果，平均相关系数为 0.86±0.05，平均相对误差为 0.06±0.03。在 3D ARI 图谱和 CARTO 心内膜 ARI 图谱中最长 ARI 部位之间的平均定位误差为 4.5±2.3mm。这些结果表明，ARI 成像可以作为评估心室复极整体模式的一种替代方法，有助于未来研究整体复极离散性与心脏心律失常易感性之间的关系。
