心脏钙处理和兴奋-收缩偶联的新见解。
New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.
机构信息
Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Fisciano, Italy.
出版信息
Adv Exp Med Biol. 2018;1067:373-385. doi: 10.1007/5584_2017_106.
Abstract
Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.
摘要
兴奋-收缩（EC）偶联表示在收缩细胞中将电刺激转化为机械输出。多项研究表明，钙（Ca）在这一过程中起着关键作用。在这里，我们全面而更新地描述了心脏 Ca 处理中涉及的主要系统，这些系统确保了功能性 EC 偶联及其病理改变，主要与心力衰竭有关。
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