Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Fisciano, Italy.
Adv Exp Med Biol. 2018;1067:373-385. doi: 10.1007/5584_2017_106.
Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.
兴奋-收缩（EC）偶联表示在收缩细胞中将电刺激转化为机械输出。多项研究表明，钙（Ca）在这一过程中起着关键作用。在这里，我们全面而更新地描述了心脏 Ca 处理中涉及的主要系统，这些系统确保了功能性 EC 偶联及其病理改变，主要与心力衰竭有关。
